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Previous studies have demonstrated widespread regional abnormalities in blood oxygen level-dependent (BOLD) amplitude of low frequency fluctuation (ALFF) in psychotic disorders. How regional ALFF is related to functional…
Isolated REM sleep behavior disorder is a high-risk prodromal syndrome for Lewy body diseases but highly heterogeneous. Neurophysiologic markers resolving this heterogeneity and predicting phenoconversion remain limited…
Olfactory decline is an early sign of Parkinsonâs disease (PD), often preceding motor symptoms by years to decades. However, because olfactory impairment is also common in healthy and diseased aging, current olfactory…
A recent publication [1] in this journal reported findings from the use of the tracer [11C]K-2 for PET imaging of brain AMPA receptors in patients with major psychiatric disorders. [11C]K-2 functions by a pro-drug-like…
Ants and bees are known to use spatial memories to navigate to fixed locations, such as a nest. Virtual-reality experiments in which Drosophila fruit flies follow fictive odour plumes now show that these insects use…
Thalamic deep brain stimulation (DBS) is an established neuromodulatory treatment option for drug-resistant epilepsy (DRE), but presurgical markers associated with the postoperative response remain incompletely…
Feeding is tightly regulated by hypothalamic circuits that integrate circadian and metabolic cues, yet the neuromodulatory systems coordinating these signals remain incompletely understood. Cholinergic neurons within the…
V2a interneurons are excitatory neurons found throughout the hindbrain and spinal cord, two regions that arise from distinct progenitors during embryonic development. Whether this lineage difference shapes mature gene…
Na+,K+-ATPases establish and maintain the vital electrochemical gradients for Na+ and K+ across animal cell membranes. The protein is a ternary complex composed of α, β and FXYD subunits, of which isoforms that fine-tune…
Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could…
Traditional models of brain connectivity primarily focus on pairwise interactions, overlooking collective dynamics among multiple regions. Although many higher-order interaction (HOI) metrics have been proposed, their…
Dysfunctional mitophagy is proposed as a key component of Alzheimerâs disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a…
The entorhinal–hippocampal circuit plays a central role in episodic memory, yet the contribution of the medial entorhinal cortex (MEC) ultraslow (< 0.01 Hz) oscillation remains poorly understood. Here, we develop a…
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes…
Hearing loss is a major modifiable risk factor for Alzheimerâs disease (AD), but how auditory deprivation engages specific neural circuits, particularly in a sex-dependent manner, to promote amyloid pathology remains…
Microglia, the brainâs resident immune cells, are increasingly recognized as key regulators of brain physiology and behavior. However, their specific role in affective states remains controversial, with studies…
Low-dimensional manifolds underlie mental and cognitive representations, and characterizing individual differences is critical to neuropsychiatric research. Existing manifold learning methods either distort…
Memory formation relies on the reorganization of neural activity patterns during experience that persist in subsequent sleep. How these processes promote learning while preserving established memories remains unclear…
Several modifiable risk factors for dementias have been identified including socio-economic status and environmental exposures â however, how these population-level risks relate to individual risk remains elusive. To…
Persistent dizziness is a frequent and disabling symptom after retrosigmoid microsurgery for vestibular schwannoma (VS), negatively affecting quality of life. While vestibular outcomes are well studied, the contribution…
Understanding how scientific research informs policy is central to the social sciences, yet systematic evidence of this process remains limited. Bearing in mind that uses can take many different forms, we present a…
Neuroimaging studies using a variety of techniques have demonstrated abnormal patterns of spontaneous brain activity in patients with late-life depression (LLD). However, the findings are variable and often inconsistent…
Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight…
Shift work is associated with an increased risk of sleep disorders, yet tailored prevention and treatment programs remain rare and understudied. Cognitive behavioral therapy for insomnia is the first-line treatment for…
The growing integration of digital technologies into healthcare requires understanding the impact of different consultation modalities on patient stress, memory and perceived credibility. This study compared different…
Health-related quality of life (HRQoL) among breast cancer survivors varies widely from diagnosis through post-treatment; however, distinct recovery patterns remain underexplored. In this study, we used a person-centered…
Guided by social cognitive theory, this study explored the direct and serial chain-mediating relationships between peer assessment quality (PAQ) and English writing ability (EWA), with learning engagement (LE) and…
Street vegetation can play an important multifunctional role in increasing green spaces for more just, healthy and sustainable cities. However, there is still limited knowledge on how greenery exposure and seasonal…
Altercentric and egocentric biases (AB, EB) refer to the impact of another agentâs/own perspective on the speed with which one can report oneâs own/another visual perspective respectively. These biases are known to…
Although the link between depression and social media addiction in adolescents is well established, the specific mechanisms driving this association remain underexplored. This study aims to investigate how physical…
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