Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceHistone variants diversify chromatin features and regulate genome packaging, expression, and protection. The conserved…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceComputational models can simulate disease to generate virtual clinical trials informing therapeutic selection. Predictions…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceSocial evolution is a potent force, shaping the expression of many important behavioral traits based on changes in a variety…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceEngineered organoid morphogenesis is an enabling concept that transforms heterogeneous, stochastic cell behavior into a…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceAbnormal aggregation of the neuronal protein α-synuclein is central to Parkinson’s disease and related disorders, yet…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceAlzheimer’s disease accounts for over two-thirds of dementia cases worldwide. A key factor in Alzheimer’s disease pathology is…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceMitochondrial oxidative phosphorylation impairment is a hallmark of aging and it has been implicated in several neurological…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceMany animals navigate diverse odor plumes by smell. While upwind movement upon odor detection is well established, less is…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceLiving cells primarily transmit traits through genetic inheritance, whereas the contribution of nongenetic materials to…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificancePlants face fundamental tradeoffs between growth and defense due to limited resources, yet little is known about tradeoffs…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceDrug repurposing offers a cost-effective strategy for accelerating therapeutic development. This study identifies trazodone…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceBroadly neutralizing antibodies (bnAbs) targeting the HIV-1 membrane-proximal external region (MPER) engage both viral protein…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceZhao et al. identified a novel epigenetic mechanism whereinSNORD78competitively binds to the Lys221 ubiquitination site of the…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceScientific conclusions hinge not only on data but on analytic decisions that published results seldom make explicit. Using…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificancePersistent activation of the integrated stress response (ISR) is causally linked to cognitive dysfunction across neurological…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceToxin-antidote (TA) systems are selfish genetic elements thought to be widespread in eukaryotes, yet their origins and…
Proceedings of the National Academy of Sciences, Volume 123, Issue 29, July 2026. SignificanceA novel form of synaptic plasticity in the hippocampus referred to as presynaptic homeostatic plasticity (PHP) has recently…
Banning smartphones in schools may help reduce some administrative burdens, but it does not appear to bring significant improvements to students’ mental health or overall well-being, according to a ...
The authorities of Tyavarekoppa Tiger and Lion Safari (Shivamogga zoo) conducted a behavioural study of a tigress rescued from a human-animal conflict area, in collaboration with Kateel Ashok Pai ...
A new study led by our Psychology Department has revealed that children play a much bigger role in shaping human culture than previously thought. The research, published in the journal Behavioural and ...
Exercise doesn't just make the heart stronger. It also rewires the nerves that regulate it, a discovery that could pave the way for more personalized treatments for common heart conditions such as arrhythmias and angina.
Background The effectiveness of vaccines in protecting against disease wanes with increasing age. There is some evidence that psychological wellness and vitamin D supplementation can increase vaccine effectiveness in…
Self-harm is a major health concern amongst young people that is increasing in prevalence. Cognitive analytic therapy (CAT) is a relational, integrative psychotherapy that is theoretically consistent with our growing…
Sexual assault is a significant public health and human rights concern in Indonesia and is associated with post-traumatic stress disorder (PTSD) symptoms among women survivors. Limited evidence exists on how Indonesian…
Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at risk for problematic digital use (PDU), which is better characterised by loss of control and functional impairment than by screen time alone. The…
Population aging has raised growing concerns about the psychological well-being of middle-aged and older adults. Although loneliness and social participation are closely linked, their long-term interplay remains…
Following publication of the original article [1], the authors identified the errors below: Table 3 has been incorrectly placed in the discussion section. The footnote “2significant p-values in bold” in Table 3 should be…
Under Trump, the Office of Management and Budget has proposed a rule change that would shift authority for grant making to political appointees. Experts say it could negatively affect U.S. science.
Erin Morrow (Cognitive Area) received the 33rd annual Samuel Eiduson Student Lectures Award from the Brain Research Institute. Established in honor of Dr. Samuel Eiduson, the founding Chair of the Neuroscience…
Matthias Mehl, a social psychologist at the University of Arizona, who helped conduct the study, recently set out to replicate his findings with a larger data set: audio from more than two thousand people between the…