Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could…
Traditional models of brain connectivity primarily focus on pairwise interactions, overlooking collective dynamics among multiple regions. Although many higher-order interaction (HOI) metrics have been proposed, their…
Dysfunctional mitophagy is proposed as a key component of Alzheimerâs disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a…
The entorhinal–hippocampal circuit plays a central role in episodic memory, yet the contribution of the medial entorhinal cortex (MEC) ultraslow (< 0.01 Hz) oscillation remains poorly understood. Here, we develop a…
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes…
Hearing loss is a major modifiable risk factor for Alzheimerâs disease (AD), but how auditory deprivation engages specific neural circuits, particularly in a sex-dependent manner, to promote amyloid pathology remains…
Microglia, the brainâs resident immune cells, are increasingly recognized as key regulators of brain physiology and behavior. However, their specific role in affective states remains controversial, with studies…
Low-dimensional manifolds underlie mental and cognitive representations, and characterizing individual differences is critical to neuropsychiatric research. Existing manifold learning methods either distort…
Memory formation relies on the reorganization of neural activity patterns during experience that persist in subsequent sleep. How these processes promote learning while preserving established memories remains unclear…
Several modifiable risk factors for dementias have been identified including socio-economic status and environmental exposures â however, how these population-level risks relate to individual risk remains elusive. To…
Altercentric and egocentric biases (AB, EB) refer to the impact of another agentâs/own perspective on the speed with which one can report oneâs own/another visual perspective respectively. These biases are known to…
Insomnia symptoms are common and have been associated with disrupted circadian rhythms, altered eating behaviors, and poorer diet quality. Cognitive Behavioral Therapy for Insomnia (CBTi) is recommended as a first-line…
A study conducted by the University of Barcelona provides new evidence on the role of the glymphatic system, which clears waste from the brain, in neurodegenerative diseases. The study shows that patients with conditions…
Glioblastoma is a malignant brain tumor and is among the most aggressive cancers in humans. Despite multimodal therapy with surgery, radiation and chemotherapy, there is still no cure. A major reason is the tumor's…
Researchers have developed a new artificial intelligence-based method that could significantly improve the detection and classification of brain tumors from MRI scans, achieving higher accuracy than conventional…
Scientists at Virginia Tech's Fralin Biomedical Research Institute at VTC have discovered how an experimental therapy can help brain cells overcome the effects of a disease-causing genetic deletion. Instead of repairing…
Published in the Alzheimer’s & Dementia Journal, the study said that even though India’s ageing population faces a ‘dementia burden’, data on what its risk factors actually are is still quite limited.
Eye contact between infants and adult speakers synchronizes their brainwaves to enable language acquisition.
Researchers developed a brain-inspired AI model modeled on hippocampal mechanisms including cognitive maps and stochastic calculations.
A new pan-European study has identified the key behavioral factors that influence whether health care professionals prescribe new, novel or nonroutine treatments for patients with neurodegenerative diseases.
Researchers introduced Core2Edge, a human-tissue model combining patient-derived glioblastoma organoids with brain slices.
Consistent daily routines for waking, eating, and sleeping reduces physical pain and depressive symptoms in older adults, buffering against the negative health impacts of insomnia by synchronizing circadian rhythms.
Researchers at Kennedy Krieger Institute and Johns Hopkins Medicine have discovered that memory consolidation during sleep depends on coordinated activity among three brain regions, and disruptions to this activity can…
Integrated home-visit intervention package providing health, nutrition, early stimulation, and maternal support significantly reduces anemia and stunting while boosting neurodevelopment in small-for-gestational-age…
A twice-daily oral CBD/THC formulation rapidly and significantly reduces end-of-life agitation in hospice-eligible dementia patients, achieving sustained symptom relief through 12 weeks.
study shows NAC antioxidant therapy bypasses 22q11.2 deletion syndrome deficits via alternative gene networks.
Many teenagers study a second language at school, often wondering whether they will ever use it. New research suggests there may be an unexpected reward. According to scientists presenting their work ...
Many young parents actively enroll their children in early development programs, sports clubs and creative activities. But how much is too much? Anastasia Gaurilyus, a neuropsychologist, associate ...
New blood tests that detect early changes associated with Alzheimer's disease are making diagnosis easier and more accessible to patients because they are less invasive than the brain scans or spinal taps typically used…
Researchers found models with about 3 billion parameters perform almost as well as those with up to 14 billion, potentially reducing the computing power needed for brain research.