Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally…
Alzheimer’s disease (AD) is a chronic, multifactorial neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Pathological hallmarks include extracellular amyloid-β (Aβ) deposition and…
Upper limb impairment is one of the most common motor consequences after stroke, and valid assessment tools are essential for evaluating motor capacity. The Wolf Motor Function Test (WMFT) is widely used to measure upper…
Standing up from sitting is a common yet mechanically demanding activity of daily living. Those with motor impairments often have difficulties performing sit-to-stand transfers independently. Robotic devices can help…
Women experience addiction differently than men, with the nature and magnitude of these differences dependent on the clinical phenotype (e.g., progression to addiction vs. relapse vulnerability) and context (e.g., phase…
HIV-Tat and morphine synergistically exacerbate neuroinflammation and DNA damage, yet the mechanisms linking the DNA damage response (DDR), chromatin remodeling, and innate immune activation remain poorly understood…
Astrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinsonâs disease (PD)-associated mutation LRRK2-G2019S…
Cerebrospinal fluid (CSF) is thought to facilitate brain waste clearance and immune surveillance, yet its compartmentalization remains unclear. Previous work, using invasive dynamic intrathecal MRI contrast imaging…
Neural manifolds refer to the low-dimensional shapes formed by populations of spiking neurons. This intrinsic population geometry can be physically emulated by electronic devices, facilitating near-training-free…
The astringency surface sub-quality is pivotal to red wine perception, yet its neural bases remain unclear. The approaches of non-invasive neurophysiological techniques, sensory analysis, liquid chromatography-mass…
To examine whether serial casting promotes autonomic nervous system adaptation in children with spastic CP, in comparison to ankle-foot orthoses (AFOs) and no intervention. Thirty children with spastic CP (aged 6–12…
Neuronal polarization is essential for functional compartmentalization, enabling dendritic synaptic integration and axonal action potential generation. Although structural differences in mitochondria across compartments…
Reshaping cortical circuits through stimulation represents an emerging therapy for the restoration of cognitive function1â5, yet the biological mechanisms that underlie its effects remain largely unexplored in humans…
G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual…
Spontaneous biological oscillations are typically attributed to specific architectures within metabolic or gene regulatory networks. Here, we uncover a more general mechanism arising from the interplay between cellular…
Psychological stress is a major precipitating factor for neuropsychiatric disorders, and the gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host…
Understanding how adverse life events trigger stress-related behavioural changes remains an unresolved challenge. The amygdala is integral to emotion and stress responses1 and comprises astrocytes, neurons and other…
Brains extract relations between objects and concepts and integrate them into cognitive maps for decision-making. But it remains unclear how they achieve that. Here we present a rigorous theory showing that single…
Human social interaction emerges through coordinated behavior, emotion, and physiology. Biobehavioral synchrony supports stress regulation, attachment, and socio-emotional development, yet its manifestation in…
In the past, cognitive illusions, such as the repetition-based illusory truth and certainty effects, were primarily studied in experimental settings that were far removed from real-world conditions. However, information…
Transcranial focused ultrasound stimulation (tFUS) is an emerging non-invasive neuromodulation technique with unique advantages in targeting deep brain structures with high precision. In this study, we investigated the…
A team of scientists who carried out significant research on the causes of dementia have named three things to avoid. Researchers at NYU Langone Health in the US studied more than 12,000 people to ...
A trove of recent articles bemoan the collapse in recreational reading among younger Americans, with COVID-related reading declines, artificial intelligence and social media often described as causes.
The number of Australians with dementia is forecast to more than double in the next 40 years to almost 1.1 million people, most of them women.
Workplace exposure to pesticides (herbicides and insecticides) is linked to a 60%–70% heightened risk of the most common form of motor neuron disease—amyotrophic lateral sclerosis, or ALS for short—finds a synthesis of…
IBC-Ab002, an anti-PD-L1 immunotherapy targeting systemic immune aging, is safe and reduces markers of neuronal damage in Alzheimer's patients.
A study published in the Journal of Political Economy provides the first causal evidence that improving sleep can directly enhance academic performance.
Eating less sugar during pregnancy and a child's first two years may support long-term brain health and significantly lower the risk of developing dementia later in life.
Ears are built to listen to sounds from the world around us, but for some people, the sound comes from within. Tinnitus causes people to hear ringing or other noises in one or both ears or in their heads, even when there…
Sudden, hard-to-explain market gyrations involving billions of dollars are often triggered by a lack of transparency, new academic research suggests.