Blocking the glycine transporter SLC6A20 restored important brain signaling and improved social, communication, and repetitive behaviors in autism-related mouse models. The treatment also worked in human brain organoids…
An international study led by Mayo Clinic researchers has identified interleukin-6 (IL-6) receptor blockers as a promising option for preventing relapses in myelin oligodendrocyte glycoprotein antibody-associated disease…
The pace at which a person walks down a hallway looks like the most ordinary thing in the world, yet a growing body of research treats it as a window into the brain. Scientists studying aging have ...
New research from NYU Langone Health found that people who avoid three vascular risk factors in middle age had about 13 more dementia-free years.
The risk of cognitive decline increases as we get older, with about 42% of Americans over the age of 55 expected to develop dementia during their lives. The research, published Wednesday in the ...
Although dementia traditionally affects older people there are still several ways in which we can help to prevent or delay it while we're still young. Doctors have previously looked into dementia to ...
Many people worry about developing dementia as they get older and wonder if there's anything they can do to stop it. The honest answer is that there is currently no proven way to prevent dementia, ...
There are still opportunities in midlife to prevent dementia or delay its onset, a new study finds.
Many people worry about developing dementia as they get older and wonder if there's anything they can do to stop it. The honest answer is that there is currently no proven way to prevent dementia, ...
However, a new study shows a simple change in how you walk may reduce your dementia risk by 50% —and it has nothing to do with walking 10,000 steps per day or for 15 minutes after every meal. Spoiler ...
New research finds that people who steer clear of key cardiovascular hazards at midlife live much longer before developing dementia.
Many people worry about losing their memory as they grow older, but a new study suggests that some of the most powerful ways to protect the brain may begin decades before symptoms appear. Researchers ...
Here's what the latest research reveals about the psychopathic brain, reward-seeking and why biology is only part of the story The post Is there really a ‘psychopath brain’? What neuroscience reveals ...
Building on the EMI framework that conceptualises consciousness, cognition, and behaviour as emergent phenomena arising from dynamic interactions among energy, mass, and information, this article extends the model into…
BackgroundAnti-NMDAR encephalitis is a common form of autoimmune encephalitis with marked clinical heterogeneity. The cerebrospinal fluid (CSF)/serum albumin quotient (QAlb) is a clinically accessible marker reflecting…
IntroductionNeural development is regulated by several spatiotemporally changing factors, which are essential for enabling neurons to develop functional networks, during early developmental stages. Additionally, external…
A multitude of studies have confirmed the essential role of the hippocampus in the acquisition and updating of associative experience. In rodents, spatial memories are dependent on hippocampal information processing and…
Autism spectrum disorder (ASD) shows high variability in brain structure and behavior, complicating identification of biologically meaningful subtypes and their neuroanatomical and molecular bases. To address this, we…
Psychopathy is a personality construct characterized by emotional detachment, impulsivity, and antisocial tendencies. Despite a clinical prevalence of 1%, the biological underpinnings of psychopathy remain poorly…
Orexin receptor 2 (OX2R)-selective agonists have potent wake-promoting effects and could be a promising treatment for sleep/wake disorders, such as narcolepsy type 1. However, OX2R agonists may cause cardiovascular (CV)…
Excitation-Inhibition (E/I) balance is a system-level principle governing healthy neuronal information processing. Its disruption has been implicated in the pathophysiology of multiple sclerosis (MS), yet in vivo…
The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly…
Denervated skeletal-muscle atrophy poses a significant challenge in peripheral neurosurgery, with limited recovery of muscle function affecting patients’ quality of life. This study explores the role of the immune…
Fast, highly constrained sensorimotor acts require rapid coordination of distributed cortical systems on subsecond timescales. Here, we used source-resolved magnetoencephalography to characterise time-locked cortical…
Most mammalian offspring are born helpless and depend on sustained parental care for survival, making caregiving one of the most conserved and essential behavioural repertoires in mammals. Yet infant-directed behaviours…
One-shot learningâthe ability to form memories after a single, brief salient eventâis essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies…
Chronically implanted brain-computer interfaces (BCI) for speech have demonstrated restoration of speech communication for people with severe motor impairment. Yet maintaining stable long-term performance remains a…
Parentâoffspring interactions play an important role in offspring survival. Although there is evidence that these interactions are predominantly guided by the right hemisphere, little is still known about the factors…
Improving behavioral performance relies on the ability to associate decisions with their positive and negative outcomes. Although neurons that associate actions with their consequences have been identified across…
Choking under evaluative pressure is often described in sport, yet its within-session neural and behavioural correlates in youth athletes remain poorly characterised. In this exploratory, fixed-order study we asked…